Current trends in initial management of hypopharyngeal cancer: The declining use of open surgery
Identifieur interne : 000248 ( France/Analysis ); précédent : 000247; suivant : 000249Current trends in initial management of hypopharyngeal cancer: The declining use of open surgery
Auteurs : Robert P. Takes [Pays-Bas] ; Primož Strojan [Slovénie] ; Carl E. Silver [États-Unis] ; Patrick J. Bradley [Royaume-Uni] ; Missak Haigentz Jr. [États-Unis] ; Gregory T. Wolf [États-Unis] ; Ashok R. Shaha [États-Unis] ; Dana M. Hartl [France] ; Jan Olofsson [Norvège] ; Johannes A. Langendijk [Pays-Bas] ; Alessandra Rinaldo [Italie] ; Alfio Ferlito [Italie] ; David W. EiseleSource :
- Head & Neck [ 1043-3074 ] ; 2012-02.
Abstract
Squamous cell carcinoma of the hypopharynx represents a distinct clinical entity. Most patients present with significant comorbidities and advanced‐stage disease. The overall survival is relatively poor because of high rates of regional and distant metastasis at presentation or early in the course of the disease. A multidisciplinary approach is crucial in the overall management of these patients to achieve the best results and maintain or improve functional results. Traditionally, operable hypopharyngeal cancer has been treated by total (occasionally partial) laryngectomy and partial or circumferential pharyngectomy, followed by reconstruction and postoperative radiotherapy in most cases. Efforts to preserve speech and swallowing function in the surgical treatment of hypopharyngeal (and laryngeal) cancer have resulted in a declining use of total laryngopharyngectomy and improved reconstructive efforts, including microvascular free tissue transfer. There are many surgical, as well as nonsurgical, options available for organ and function preservation, which report equally effective tumor control and survival. The selection of appropriate treatment is of crucial importance in the achievement of optimal results for these patients. In this article, several aspects of surgical and nonsurgical approaches in the treatment of hypopharyngeal cancer are discussed. Future studies must be carefully designed within clearly defined populations and use uniform terminology and standardized functional assessment and declare appropriate patient or disease endpoints. These studies should focus on improvement of resultsx, without increasing patient morbidity. In this respect, technical improvements in radiotherapy such as intensity‐modulated radiotherapy, advances in supportive care, and incorporation of newer systemic agents such as targeted therapy, are relevant developments. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
Url:
DOI: 10.1002/hed.21613
Affiliations:
- France, Italie, Norvège, Pays-Bas, Royaume-Uni, Slovénie, États-Unis
- Groningue (province), Gueldre, Michigan, État de New York, Île-de-France
- Groningue, Nimègue, Paris
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ISTEX:EB080EE49AF7AF433CD5FF8E5A27ACEE00B42A36Le document en format XML
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Takes</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Otolaryngology–Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Strojan, Primoz" sort="Strojan, Primoz" uniqKey="Strojan P" first="Primož" last="Strojan">Primož Strojan</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Radiation Oncology, Institute of Oncology, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Silver, Carl E" sort="Silver, Carl E" uniqKey="Silver C" first="Carl E." last="Silver">Carl E. Silver</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Surgery and Otolaryngology–Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Bradley, Patrick J" sort="Bradley, Patrick J" uniqKey="Bradley P" first="Patrick J." last="Bradley">Patrick J. Bradley</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Otorhinolaryngology–Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Haigentz Jr, Missak" sort="Haigentz Jr, Missak" uniqKey="Haigentz Jr M" first="Missak" last="Haigentz Jr.">Missak Haigentz Jr.</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Division of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Wolf, Gregory T" sort="Wolf, Gregory T" uniqKey="Wolf G" first="Gregory T." last="Wolf">Gregory T. Wolf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Shaha, Ashok R" sort="Shaha, Ashok R" uniqKey="Shaha A" first="Ashok R." last="Shaha">Ashok R. Shaha</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Head and Neck Service, Memorial Sloan‐Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Hartl, Dana M" sort="Hartl, Dana M" uniqKey="Hartl D" first="Dana M." last="Hartl">Dana M. Hartl</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Otolaryngology–Head and Neck Surgery, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Phonétique et de Phonologie, Sorbonne Nouvelle, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Olofsson, Jan" sort="Olofsson, Jan" uniqKey="Olofsson J" first="Jan" last="Olofsson">Jan Olofsson</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Otolaryngology–Head and Neck Surgery, Haukeland University Hospital, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Langendijk, Johannes A" sort="Langendijk, Johannes A" uniqKey="Langendijk J" first="Johannes A." last="Langendijk">Johannes A. 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Eisele</name></author></analytic><monogr></monogr><series><title level="j" type="main">Head & Neck</title><title level="j" type="alt">HEAD AND NECK</title><idno type="ISSN">1043-3074</idno><idno type="eISSN">1097-0347</idno><imprint><biblScope unit="vol">34</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="270">270</biblScope><biblScope unit="page" to="281">281</biblScope><biblScope unit="page-count">12</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-02">2012-02</date></imprint><idno type="ISSN">1043-3074</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1043-3074</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Squamous cell carcinoma of the hypopharynx represents a distinct clinical entity. Most patients present with significant comorbidities and advanced‐stage disease. The overall survival is relatively poor because of high rates of regional and distant metastasis at presentation or early in the course of the disease. A multidisciplinary approach is crucial in the overall management of these patients to achieve the best results and maintain or improve functional results. Traditionally, operable hypopharyngeal cancer has been treated by total (occasionally partial) laryngectomy and partial or circumferential pharyngectomy, followed by reconstruction and postoperative radiotherapy in most cases. Efforts to preserve speech and swallowing function in the surgical treatment of hypopharyngeal (and laryngeal) cancer have resulted in a declining use of total laryngopharyngectomy and improved reconstructive efforts, including microvascular free tissue transfer. There are many surgical, as well as nonsurgical, options available for organ and function preservation, which report equally effective tumor control and survival. The selection of appropriate treatment is of crucial importance in the achievement of optimal results for these patients. In this article, several aspects of surgical and nonsurgical approaches in the treatment of hypopharyngeal cancer are discussed. Future studies must be carefully designed within clearly defined populations and use uniform terminology and standardized functional assessment and declare appropriate patient or disease endpoints. These studies should focus on improvement of resultsx, without increasing patient morbidity. In this respect, technical improvements in radiotherapy such as intensity‐modulated radiotherapy, advances in supportive care, and incorporation of newer systemic agents such as targeted therapy, are relevant developments. © 2010 Wiley Periodicals, Inc. Head Neck, 2012</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Slovénie</li><li>États-Unis</li></country><region><li>Groningue (province)</li><li>Gueldre</li><li>Michigan</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Groningue</li><li>Nimègue</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Eisele, David W" sort="Eisele, David W" uniqKey="Eisele D" first="David W." last="Eisele">David W. Eisele</name></noCountry><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Takes, Robert P" sort="Takes, Robert P" uniqKey="Takes R" first="Robert P." last="Takes">Robert P. Takes</name></region><name sortKey="Langendijk, Johannes A" sort="Langendijk, Johannes A" uniqKey="Langendijk J" first="Johannes A." last="Langendijk">Johannes A. Langendijk</name></country><country name="Slovénie"><noRegion><name sortKey="Strojan, Primoz" sort="Strojan, Primoz" uniqKey="Strojan P" first="Primož" last="Strojan">Primož Strojan</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Silver, Carl E" sort="Silver, Carl E" uniqKey="Silver C" first="Carl E." last="Silver">Carl E. Silver</name></region><name sortKey="Haigentz Jr, Missak" sort="Haigentz Jr, Missak" uniqKey="Haigentz Jr M" first="Missak" last="Haigentz Jr.">Missak Haigentz Jr.</name><name sortKey="Shaha, Ashok R" sort="Shaha, Ashok R" uniqKey="Shaha A" first="Ashok R." last="Shaha">Ashok R. Shaha</name><name sortKey="Wolf, Gregory T" sort="Wolf, Gregory T" uniqKey="Wolf G" first="Gregory T." last="Wolf">Gregory T. Wolf</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Bradley, Patrick J" sort="Bradley, Patrick J" uniqKey="Bradley P" first="Patrick J." last="Bradley">Patrick J. Bradley</name></noRegion></country><country name="France"><noRegion><name sortKey="Hartl, Dana M" sort="Hartl, Dana M" uniqKey="Hartl D" first="Dana M." last="Hartl">Dana M. Hartl</name></noRegion><name sortKey="Hartl, Dana M" sort="Hartl, Dana M" uniqKey="Hartl D" first="Dana M." last="Hartl">Dana M. Hartl</name></country><country name="Norvège"><noRegion><name sortKey="Olofsson, Jan" sort="Olofsson, Jan" uniqKey="Olofsson J" first="Jan" last="Olofsson">Jan Olofsson</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Rinaldo, Alessandra" sort="Rinaldo, Alessandra" uniqKey="Rinaldo A" first="Alessandra" last="Rinaldo">Alessandra Rinaldo</name></noRegion><name sortKey="Ferlito, Alfio" sort="Ferlito, Alfio" uniqKey="Ferlito A" first="Alfio" last="Ferlito">Alfio Ferlito</name><name sortKey="Ferlito, Alfio" sort="Ferlito, Alfio" uniqKey="Ferlito A" first="Alfio" last="Ferlito">Alfio Ferlito</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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